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- Created 2012-03-19
occurs when an extracellular signaling molecule activates a
cell surface receptor
. In turn, this receptor alters intracellular molecules creating a response. There are two stages in this process:
1. A signaling molecule activates a specific receptor protein on the cell membrane.
2. A second messenger transmits the signal into the cell, eliciting a physiological response.
In either step, the signal can be amplified. Thus, one signalling molecule can cause many responses. A signal transduction functions much like a switch.
from Wikipedia (last updated: 13 December), licensed under
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Netpath - A curated resource of signal transduction pathways in humans
Signal Transduction - The Virtual Library of Biochemistry and Cell Biology
''Science'''s STKE - Signal Transduction Knowledge Environment
UCSD-Nature Signaling Gateway
A Cell Based Immunocytochemical Assay For Monitoring Kinase Signaling Pathways And Drug Efficacy (PDF)
Signaling PAthway Database
Cell cycle - Homo sapiens (human)
http://pid.nci.nih.gov/ Pathway Interaction Database
Two-component regulatory system
G protein-coupled receptor
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