In Greek history, Hellenistic Greece corresponds to the period between the death of Alexander the Great in 323 BC and the annexation of the classical Greek heartlands by Rome in 146 BC. This entry focuses on the history of 'Greece proper' (effectively the area of modern Greece) during this period.

During the Hellenistic period the importance of Greece proper within the Greek-speaking world declined sharply. The great centers of Hellenistic culture were Alexandria and Antioch, capitals of Ptolemaic Egypt and Seleucid Syria respectively. Cities such as Pergamon, Ephesus, Rhodes and Seleucia were also important, and increasing urbanization of the Eastern Mediterranean was characteristic of the time.