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- Created 2012-02-18
is the process by which two
molecules exchange genetic information, resulting in the production of a new combination of
s, genetic recombination during
can lead to a novel set of genetic information that can be passed on to progeny. Most recombination is naturally occurring. During meiosis in eukaryotes, genetic recombination involves the pairing of
s. This may be followed by information exchange between the chromosomes. The information exchange may occur without physical exchange (a section of genetic material is copied from one chromosome to another, without the donating chromosome being changed)(see SDSA pathway in Figure); or by the breaking and rejoining of
strands, which forms new molecules of DNA (see DHJ pathway in Figure). Recombination may also occur during
in eukaryotes where it ordinarily involves the two sister chromosomes formed after chromosomal replication. In this case, new combinations of
s are not produced since the sister chromosomes are usually identical. In meiosis and mitosis, recombination occurs between
molecules (homologs) of DNA. In meiosis, non-sister homologous chromosomes pair with each other so that recombination characteristically occurs between non-sister homologues. In both meiotic and mitotic cells, recombination between homologous chromosomes is a common mechanism used in
Genetic recombination and recombinational
also occurs in
Recombination can be artificially induced in laboratory (in vitro) settings, producing
for purposes including
in organisms with an
adaptive immune system
is a type of site-specific genetic recombination that helps immune cells rapidly diversify to recognize and adapt to new
from Wikipedia (last updated: 05 December), licensed under
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The Holliday Model of Genetic Recombination
Animated guide to homologous recombination.
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