The Central-West Region of Brazil (Região Centro-Oeste do Brasil) is composed of the states of Goiás, Mato Grosso and Mato Grosso do Sul; along with Distrito Federal (Federal District), where Brazil's national capital, Brasília, is situated. This Region is right in the heart of Brazil, representing 18.86% of the national territory.

With the move of the country's federal capital from Rio de Janeiro to Brasília in the 60s, the construction of roads and railways to the interior of the country made the accesses easier, speeding up the population settling and contributing significantly to its development.

Mato Grosso do Sul was created in 1979, materializing the decision of the government to divide the then called state of Mato Grosso in two states to facilitate to the administration and the development of the region.

Today, Center-West is attracting many investments for agriculture, pecuary, industries and people from Southeast and Southern Brazil.

Brasília International Airport, Marechal Rondon International Airport, Campo Grande International Airport and Santa Genoveva Airport connects Center-West region with many Brazilian cities and also operates some international flights.

The Center-West is home to the University of Brasília, University Center of Brasília, Federal University of Goiás, Federal University of Mato Grosso do Sul and Federal University of Mato Grosso.